Myoscience iovera System Cleared for Treating Painful Osteoarthritic Knees

Myoscience, a company based in Fremont, California won FDA clearance for its iovera cryoneurolysis system to be used for symptom and pain relief in the knees arising from osteoarthritis. The company’s so-called Focused Cold Therapy delivery system pumps pressurized liquid nitrous oxide (N2O) to the treatment tip, where it is made to turn to a gas and become very cold. The phase change happens in tight location, creating a small and precise treatment area that can be used to create a nerve block that stops the transmission of pain.

Treatments are…

Low glycemic index diet found to lower health threats from high blood pressure

A new review of a dozen randomised controlled trials has found that a lower glycemic index (GI) diet proves effective for reducing blood pressure and, by extension, reducing heart disease risks.

Hypertension (high blood pressure) is one of the features of the metabolic syndrome and a strong risk factor for cardiovascular disease, a common long-term complication of type 2 diabetes.

Damage to nerves and blood vessels can arise from high blood sugars, and heart complications develop much more quickly if blood pressure is high. This is because tissues in the heart are especially vulnerable to increases in blood pressure.

We know from previous research that a lower-carbohydrate diet, which generally is considered a lower-GI diet, is associated with measurable decreases in blood pressure.

In this new research review, comprised of a total of 14 six-week long trials and involving 1097 healthy participants, researchers found similar results.

Thirteen of those trials reported that a reduction in glycemic index by 10 units decreased both systolic blood pressure (SBP) and diastolic blood pressure (DPB) by 1.1 and 1.3 mm Hg, respectively.

In addition to that, nine trials found that a reduction in glycemic load of 28 units reduced overall SBP and DBP by 2.0 and 1.4 mm Hg, respectively.

Taken together, these results tend to indicate that lower-GI and GL diet may benefit high blood pressure, likely because they help reduce blood sugar.

It is thought that when the body produces too much insulin and leptin in response to a higher-carb, high-GI diet, it causes blood pressure to increase. Another factor is the effects of glycation on lipoproteins leading to atherosclerosis and therefore narrowed blood vessels.

Yet, one of the first recommendations to lower blood sugar is to cut back on salt. There might be far more to maintaining a healthy blood pressure than eating a low-salt diet, which is a strategy that works for some people and fails for others.

In that sense, this review may implicitly suggest that it is time for guidelines aimed at controlling hypertension to shift focus away from salt and focus greater attention to the likely more consequential reduction in sugar.

If you are diagnosed with high blood pressure, going on a low-carb, lower-GI diet may go a long way toward controlling your levels. You can find out more by joining our Low Carb Program.


Type 2 diabetes is one of the most common long-term health conditions
Type 2 diabetes is one of the most common long-term health conditions

Type 2 diabetes mellitus is a metabolic disorder that results in hyperglycemia (high blood glucose levels) due to the body:

  • Being ineffective at using the insulin it has produced; also known as insulin resistance and/or
  • Being unable to produce enough insulin

Type 2 diabetes is characterised by the body being unable to metabolise glucose (a simple sugar). This leads to high levels of blood glucose which over time may damage the organs of the body.

From this, it can be understood that for someone with diabetes something that is food for ordinary people can become a sort of metabolic poison.

This is why people with diabetes are advised to avoid sources of dietary sugar.

The good news is for very many people with type 2 diabetes this is all they have to do to stay well. If you can keep your blood sugar lower by avoiding dietary sugar, likely you will never need long-term medication.

Type 2 diabetes was formerly known as non-insulin-dependent or adult-onset diabetes due to its occurrence mainly in people over 40. However, type 2 diabetes is now becoming more common in young adults, teens and children and accounts for roughly 90% of all diabetes cases worldwide.

How serious is type 2 diabetes?

Type 2 diabetes is a serious medical condition that often requires the use of anti-diabetic medication, or insulin to keep blood sugar levels under control. However, the development of type 2 diabetes and its side effects (complications) can be prevented if detected and treated at an early stage.

In recent years, it has become apparent that many people with type 2 diabetes are able to reverse diabetes through methods including low-carb diets, very-low-calorie diets and exercise.

For guidance on healthy eating to improve blood glucose levels and weight and to fight back against insulin resistance, join the Low Carb Program.

Following pre-diabetes or metabolic disorder, type 2 diabetes can potentially be avoided through diet and exercise.

What causes type 2 diabetes?

Type 2 diabetes occurs when the hormone insulin is not used effectively by the cells in your body. Insulin is needed for cells to take in glucose (sugar) from the bloodstream and convert it into energy.

Ineffective use of insulin results in the body becoming resistant to insulin – also known as insulin resistance, which in turn causes blood sugar levels to rise (hyperglycemia).

In advanced stages, type 2 diabetes may cause damage to insulin producing cells in…

Treating Diabetic Neuropathy

What treatments can improve pain and quality of life?

Diabetic neuropathy is a nerve disorder that the National Institute of Diabetes and Digestive and Kidney disease estimates affects about 60 to 70% of diabetic patients in some form, with the highest rates of neuropathy occurring in patients who have had diabetes for over 25 years. Although diabetic neuropathy can affect almost any organ in the body, the most common type of diabetic neuropathy is peripheral neuropathy. Peripheral neuropathy, which is often worse at night, results in tingling, numbness, and pain occurring in the hands, arms, fingers, legs, feet, and toes. The best way to prevent diabetic neuropathy is keeping glucose under control and maintaining a healthy weight, but for those who experience this painful condition, finding the best relief can often be difficult and confusing.

Previous meta-analysis studies have been published on effectiveness of different diabetic neuropathy treatments, but they do not include newer treatment options or show how treatments improve quality of life. They are also missing review data with how the meta-analysis was conducted. Building upon a previously published study from 2014, a new systemic review was conducted to “systemically assess the effect of pharmacological treatments of diabetic peripheral neuropathy (DPN) on pain and quality of life” plus a search of PubMed and Cochrane Database of systemic reviews (reviews from 2011 – March 2016), After the literature search, investigators identified the trial types, assessed the risk for bias, and pooled data on outcomes of pain intensity, health-related QOL, adverse effects, and dropouts due to adverse effects.

A total of 106 randomized controlled trials were used in the final systemic review, including trials analyzed by the previously published study. Only two medications, duloxetine and venlafaxine, had a moderate strength of evidence (SOE) compared to the low strength of evidence found with the remaining 12 study medications. As a class, serotonin-norepinephrine reuptake inhibitors (SNRIs) was found to be an effective treatment for diabetic neuropathy with the most commonly reported adverse effects of dizziness, nausea, and somnolence. Focusing on specific SNRIs, duloxetine was found to be effective for pain relief based on data from 2 new trials in addition…

6 things you should do immediately after a workout to make it count

Associated Press Workouts are important – but so is post-workout care.

In a good week, let’s say you spend seven hours working out. That might sound like a lot of gym time, but it still leaves 161 hours during which you could either undermine all of that hard work, or speed-up results with some smart lifestyle tweaks.

How you eat and what you do in the hours following exercise can dramatically impact whether your body continues to burn more calories, repair, and build muscle in all the places you want it — or if you simply plateau and don’t see any results. We spoke with Barry’s Bootcamp trainer Kate Lemere and nutritionist Lee Holmes to find out exactly which supplements to take, diet tweaks you should follow, and activities worth trying out post-workout to maximize results.

Load up on magnesium

Magnesium is used in just about everything your body does to effectively exercise and build muscle, including protein synthesis, muscle and nerve function, blood glucose control, and energy production. Because we tend to lose magnesium as we sweat during a workout, eating magnesium-rich foods — such as dark leafy greens, regular milk, almonds, cashews, sesame seeds, fish (like wild salmon and halibut), and avocado — is an important way to replenish and repair your tired body, and help you get the most out of your efforts at the gym.

If you experience painful muscle cramps, Holmes says this could be a sign that your magnesium levels are too low. “Lack of magnesium can cause muscle spasms, however when taken after exercise it can help to calm your muscles down,” she says. She also recommends taking an Epsom salt bath, which is high in magnesium and can help in the same way as an oral supplement.

Get a massage — or do it yourself

Here’s the good news: Science says you need a post-workout massage. Not only can it speed up recovery time, but a recent study found that massage after heavy exercise can also improve muscle strength. “Working out the lactic acid that builds up in your muscles can be painful, but it’s so worth the temporary pain to feel that sweet relief afterward,” Lemere says.

If you can’t justify getting a pro to rub you down after every SoulCycle class, buy a foam roller, and try some moves at home. Rollers sell for around $15 online, and there’s a ton of great, free information available about how to use them.

New Technique Improves Electric Vagus Nerve Stimulation to Treat Chronic Inflammation

Robert Butera and Yogi Patel work on electrical blocking of nerve pathways
Robert Butera and Yogi Patel work on electrical blocking of nerve pathways

Electric stimulation of the vagus nerve stimulation is a powerful emerging technique for managing a number of conditions, including chronic inflammatory diseases. Yet, while targeting biophysical mechanisms involved in inflammation, one can stimulate others that manifest in unpredictable side effects.

Researchers at Georgia Tech have invented a way of delivering electrical stimulation in a more targeted way, using an additional electrode that prevents some nerve activity while…

Type 2 diabetes UPDATE: Incurable linked condition Charcot foot can result in amputation

Type 2 diabetes: There is no cure for Charcot foot
Type 2 diabetes: There is no cure for Charcot foot

Short-term complications of Type 2 diabetes include hypoglycaemia and diabetic ketoacidosis, while long-term complications include how diabetes affects sufferers eyes, heart, kidneys, and nerves and feet.

When the condition affects the feet – a condition called neuropathy – the nerves can be severely damaged and can in severe cases result in amputation.

Diabetes can cause neuropathy as a result of high blood glucose levels damaging the small blood vessels supplying the nerves, which can prevents essential nutrients reaching the nerves.

Neuropathy can affect the sensory nerves – resulting in numbness and the inability to feel pain, which can lead people to avoid injuries which could become infected.

The nerve fibres are then damaged or disappear, which can have damaging consequences for the patient.

Type 2 diabetes: Charcot foot is a debilitating bone condition
Type 2 diabetes: Charcot foot is a debilitating bone condition
People should be aware signs and symptoms of diabetes are not always obvious and the condition is often diagnosed during GP check ups.
People should be aware signs and symptoms of diabetes are not always obvious and the condition is often diagnosed during GP check ups.

People with diabetes that have severely damaged nerves can develop a debilitating bone condition called Charcot foot, where the bones and joints in the foot are weakened.

Charcot foot can happens when an…